Quo

[john abshire]

Quo it Medus?
Translation? And particularly quo?
(I think it is “where is Medus going?”; but I have questions.) The context:
Unde venit Medus? Tusculo venit, neque is ad Villanova Iulii it. Quo it Medus? Romam it.

quo is the ablative singular of the relative pronoun qui, quae, quod (or of the interrogative pronoun quis, qui).
It must be interrogative, so it’s who, what, which, then “from who” (or “by who”) and neither makes sense.
alternatively, quo can be an adverb meaning “where”, which could make sense, so I assume this is it.
?

 

[Matthaeus]

yes

 

[Clemens]

Quō is specifically "to where," so even though it resembles an ablative, it actually functions as a place of motion towards, which is normally associated with the accusative. The English equivalent is "whither."

 

[Avunculus H]

Maybe you know the quote Quo vadis, domine? "Where (to) are you going, Lord?"; I guess that is the most famous sentence in Latin where quo is used in that meaning.